A recent study in Switzerland found myocardial injury in 2 (0.8%) out of 237 men who took the Moderna booster shot, but such injury was found in 20 (3.7%) out of 540 women who took it. At 30 days follow-up, neither of the two men, and only 9 of the women, got their high-sensitivity cardiac troponin T (hs-cTnT) levels down below 6 ng/L.
While the original authors thought it wasn’t such a bad thing for half of those injured to fail to get down below 6 ng/L (because of basing risk merely on usual percentiles), the second bulletpoint at the top right of this document reveals that not getting it down below 6 ng/L is a problem, because that means elevated relative risk of cardiovascular disease.
At the original study linked to at top, you can scroll down almost to the bottom until Figure 2, Panel B, where they show you the 30-day evolution of troponin levels post-booster in those 22 total individuals who reached levels associated with myocardial injury.
Here are my notes regarding this panel B:
[click to enlarge]
Evidence suggests that Moderna boosters make it so that 1 in 50 (2%) women — and almost 1 in 100 (0.8%) men — have persistingly-elevated risk of cardiovascular disease, by way of their high-sensitivity cardiac troponin T levels remaining at 6 ng/L or above by Day 30.
Reference
[30-day cardiac troponin T levels] — Sex-specific differences in myocardial injury incidence after COVID-19 mRNA-1273 Booster Vaccination. Figure 2; Panel B. https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejhf.2978
[CVD risk whenever hs-cTnT remains at 6 ng/L or above] — Cleveland Heart Lab. https://www.clevelandheartlab.com/wp-content/uploads/2020/01/CHL-Troponin-T-High-Sensitivity-clinical.pdf
[with hs-cTnI, anything above 5 ng/L represents elevated risk] — High-Sensitivity Troponin and the Application of Risk Stratification Thresholds in Patients With Suspected Acute Coronary Syndrome. Circulation. 2019;140:1557–1568. Originally published 1 Sep 2019. https://doi.org/10.1161/CIRCULATIONAHA.119.042866