NOTE: This post was updated on 27 Oct 2023 to correct an error in image notes.
According to the World Health Organization (WHO), in order for a “COVID vaccine” to be acceptable, it must lead to relative risk of severe COVID of .30 (cut severe COVID by about 70%) and have so much evidence behind it, that even the the upper bound on the relative risk is no higher than about .70 (30% reduction):
Though public health officials may never mention it, one substance which meets official WHO standards for an effective therapeutic for COVID is vitamin D (orange and purple markings added):
The summary odds ratio of 0.28 indicates a central estimate of effectiveness of almost 70% reduction in ICU admission, and the upper bound of 0.39, considering the control group ICU admission rate of 21%, indicates an effectiveness of 55% — meeting both of the WHO standards.
The authors performed Trial Sequential Analysis to determine if more studies are necessary to confirm the findings or if the findings, on their own, are already conclusive.
They discovered that the effect of vitamin D on ICU admission rates is already conclusive.
After Omicron BA.2 (after Jun 2022), one of the substances which failed to meet WHO standards for effectiveness was the COVID booster shot:
Against all hospitalization (a very crude indicator of severity), the central estimate, even on the 4th dose, failed to reach the 70% minimum acceptable effectiveness estimate.
Evidence suggests that COVID shots should be removed from the market, and that vitamin D should be used, instead.
Reference
[minimum acceptable efficacy against severe COVID is 70%-80% with a 30% lower bound] — WHO. https://www.who.int/tools/target-product-profile-database/item/tpp--for-covid-19-vaccines
[booster shot VE against hospitalization is below 70%] — CDC Presentation. Slide 14. https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2022-09-01/04-covid-link-gelles-508.pdf
[vitamin D “definitively” cuts ICU admission rates] — Argano C, Mallaci Bocchio R, Natoli G, Scibetta S, Lo Monaco M, Corrao S. Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis. Pharmaceuticals (Basel). 2023 Jan 16;16(1):130. doi: 10.3390/ph16010130. PMID: 36678627; PMCID: PMC9864223. https://pubmed.ncbi.nlm.nih.gov/36678627/